Physiological aging linked to neurodegeneration

What does link neurodegeneration to aging? In our recent Science Advances paper we addressed this issue by measuring thousands of protein lifetimes and studying the factors influencing protein turnover changes in the aging brain. Thanks to all collaborators at the University Medical Centre Göttingen (UMG), at the German Center for Neurodegenerative Diseases (DZNE) and at the MPI-multidisciplinary natural sciences!

Master Project Opportunity

Multiomics analysis of the aging mouse brain

We are looking for a Master student (m/f/d) to pursue a thesis research project of ideally six months. The student will learn the basics of proteogenomic data analysis and integration. The work will be aimed at studying mouse brain aging and will define the proteogenomic changes occurring at a global level during brain aging. All experimental data have been collected and the student will have the chance to contribute to the preparation of the final publication. As such, we foresee that the student will obtain an authorship from the thesis work.

The successful candidate will focus on integrating mRNA measures and protein level changes from several mouse models of physiological and accelerated aging. The candidate should have basic knowledge of programming/scripting languages (e.g., Perl, Python or Bash) and statistical data analysis environment (R and/or Matlab). A candidate familiar with Linux/Unix environment and basic understanding of next generation sequencing methods would be preferred.

If interested, please contact directly Dr. Fornasiero by email: efornas[at]

The NeuroLNC story is out in Science Advances!

Proud to share our latest work: neuroLNC is a new long noncoding RNA regulating presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43. Congratulations to all authors!

The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43
Keihani S., Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, Caldi Gomes L, Gärtner A, Kügler S, Urlaub H, Wren JD, Bonn S, Rizzoli, Fornasiero EF
Science Advances DOI: //